Hevylite可以通过更准确地测量完整的**球蛋白单克隆蛋白来改善对多发性骨髓瘤患者的监测。它是一组独特的实验室血清测试，可克服使用电泳方法发现的一些问题，尤其是在监测IgA多发性骨髓瘤时。
HLC分析提供了检查浆细胞生物学和**的新方法。我们能够发现以前看不见的异常情况……”
卡兹曼等。白血病2013; 27：1-2
Hevylite是一种简单的多克隆抗体血清测试，可用于检测包括多发性骨髓瘤在内的完整**球蛋白单克隆血友病。它可以：
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当SPE和IFE谱带难以解释时，准确定量单克隆蛋白
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准确定量低水平（<10 g / L）的单克隆蛋白
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确定多发性骨髓瘤的残留**
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比传统检测更早发现多发性骨髓瘤复发
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与Freelite一起提供*佳监控
该测试可提供快速准确的结果，这些结果在以下方面起着重要作用：
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诊断 -为Hevylite提供基线值，可用于监视和预后
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预后 -预测患者预后
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监测 -评估对**的反应
Hevylite是一种快速，简单且高度灵敏的实验室血清测试，用于测量完整的**球蛋白单克隆蛋白。它分别识别和测量IgGκ，IgGλ，IgAκ，IgAλ，IgMκ和IgMλ。成对评估这些蛋白质，例如IgGκ/IgGλ，以产生比率。
传统的单克隆血友病血液测试是通过扫描密度测定法进行血清蛋白电泳（SPE或SPEP），CZE（毛细管区带电泳）和/或**固定电泳（IFE）以及无血清轻链**测定。
Hevylite可以使您的实验室受益，因为它可以：
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提供比电泳方法更高的灵敏度
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克服了电泳观察到的技术难题，例如共迁移，非线性和染料饱和
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通过自动化*大化工作流程并减少“动手”时间
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提供定量结果并避免主观理解凝胶
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减少获得结果所需的不同测试的次数，尤其是对于IgA单克隆蛋白
Hevylite allows improved monitoring of Multiple Myeloma patients by more accurate measurement of intact immunoglobulin monoclonal proteins. It is a set of unique laboratory serum tests which overcome some of the problems found using electrophoretic methods, especially when monitoring IgA Multiple Myeloma.
“The HLC assays allow new ways to examine plasma cell biology and disease. We are able to identify abnormalities that were previously hidden from our view…”
Katzmann et al. Leukemia 2013;27:1-2
Hevylite is a simple, polyclonal antibody serum test for intact immunoglobulin monoclonal gammopathies including Multiple Myeloma. It can:
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Accurately quantify monoclonal proteins when SPE and IFE bands are difficult to interpret
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Accurately quantify monoclonal proteins at low levels (<10 g/L)
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Identify residual disease in Multiple Myeloma
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Detect Multiple Myeloma relapse earlier than traditional testing
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Provide optimal monitoring alongside Freelite
The test provides rapid accurate results that play an important role in:
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Diagnosis - provides Hevylite a baseline value that is useful in monitoring and prognosis
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Prognosis - to predict patient outcomes
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Monitoring - to measure response to treatment
Hevylite is a quick, simple and highly sensitive laboratory serum test for measuring intact immunoglobulin monoclonal proteins. It identifies and measures IgGκ, IgGλ, IgAκ, IgAλ, IgMκ and IgMλ individually. These proteins are assessed in pairs, e.g. IgGκ/IgGλ, to produce ratios.
Traditional blood tests for monoclonal gammopathies are serum protein electrophoresis (SPE or SPEP) with scanning densitometry, CZE (capillary zone electrophoresis) and/or immunofixation electrophoresis (IFE) together with serum free light chain immunoassays.
Hevylite can benefit your lab because it:
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provides greater sensitivity than electrophoretic methods
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overcomes technical challenges observed with electrophoresis such as co-migration, non-linearity and dye saturation
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maximizes workflow through automation and reduces “hands-on” time
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provides quantitative results and avoids subjective interpretation of gels
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reduces the number of different tests needed to get a result, especially for IgA monoclonal proteins
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