参考文献:
2016
Nazirizadeh, Y. et al. Intensity interrogation
near cutoff resonance for label-free cellular profiling. Sci. Rep. 6,
24685 (2016).
French, J. B. et al. Spatial
colocalization and functional link of purinosomes with mitochondria. Science 351, 733 (2016).
Camp, N. D. et al. Dynamic mass
redistribution reveals diverging importance of PDZ-ligands for G
protein-coupled receptor pharmacodynamics. Pharmacological. Research, 105,
13-21 (2016).
Klein, A. B., Nittegaard-Nielsen, M.,
Christensen, J. T., Al-Khawaja, A., & Wellendorph, P. Demonstration of the
dynamic mass redistribution label-free technology as a useful cell-based
pharmacological assay for endogenously expressed GABAA receptors. Med. Chem.
Commun., 7, 426–432 (2016).
Klepac, K. et al. The Gq signalling
pathway inhibits brown and beige adipose tissue. Nat. Commun. 7,
10895 (2016).
2015
Hamamoto, A., Kobayashi, Y. & Saito,
Y. Identification of amino acids that are selectively involved in Gi/o
activation by rat melanin-concentrating hormone receptor 1. Cell. Signal. 27, 818–827 (2015).
Navarro, G. et al. Orexin –
Corticotropin-Releasing Factor Receptor Heteromers in the Ventral Tegmental
Area as Targets for Cocaine. J. Neurosci. 35, 6639–6653 (2015).
Wang, J. et al. RSC Advances danshen using
a label-free cell phenotypic assay. RSC Adv. 5, 25768–25776
(2015).
Rex, E. B. et al. Phenotypic Approaches
to Identify Inhibitors of B Cell Activation. J. Biomol. Screen. 20,
876–886 (2015).
Vinals, X. et al. Cognitive Impairment
Induced by Delta9- tetrahydrocannabinol Occurs through Heteromers between
Cannabinoid CB 1 and Serotonin 5-HT 2A Receptors. PLOS Biol., e1002194
(2015).
Fjellström, O. et al. Novel Zn 2+
Modulated GPR39 Receptor Agonists Do Not Drive Acute Insulin Secretion in
Rodents. PLoS One, 0145849 (2015).
Shridhar, N. et al. The experimental
power of FR900359 to study Gq-regulated biological processes. Nat. Commun. 6,
10156 (2015).
Marada, S. et al. Functional Divergence
in the Role of N-Linked Glycosylation in Smoothened Signaling. PLOS Genet., 1005473 (2015).
Brust, T. F., Hayes, M. P., Roman, D. L.
& Watts, V. J. New functional activity of aripiprazole revealed: robust
antagonism of D2 dopamine receptor-stimulated Gβγ signaling. Biochem
Pharmacol. 93, 85–91 (2015).
Camp, N. D. et al. Individual protomers
of a G protein-coupled receptor dimer integrate distinct functional modules. Cell
Discov. 1, 15011 (2015).
2014
Beckert, U. et al. Biochemical and
Biophysical Research Communications cNMP-AMs mimic and dissect bacterial
nucleotidyl cyclase toxin effects. Biochem. Biophys. Res. Commun. 451,
497–502 (2014).
Otte, M. et al. CXCL14 is no direct
modulator of CXCR4. FEBS Lett. 588, 4769–4775 (2014).
Liebscher, I. et al. A Tethered Agonist
within the Ectodomain Activates the Adhesion G Protein-Coupled Receptors GPR126
and GPR133. Cell Rep. 9, 2018–2026 (2014).
Fang, Y. Label-Free Cell Phenotypic Drug
Discovery. Comb. Chem. High Throughput Screen. 17, 566–578
(2014).
Fang, Y. Label-free drug discovery. Front.
Pharmacol. 5, 1–8 (2014).
Febles, N. K., Ferrie, A. M. & Fang,
Y. Label-Free Single Cell Kinetics of the Invasion of Spheroidal Colon Cancer
Cells through 3D Matrigel. Anal. Chem. 86, 8842–8849 (2014).
Lee, M. Y. et al. A Comparison of Assay
Performance Between the Calcium Mobilization and the Dynamic Mass
Redistribution Technologies for the Human Urotensin Receptor. Assay Drug
Dev. Technol. 12, 361–368 (2014).
Balenga, N. A. et al. Heteromerization
of GPR55 and cannabinoid CB2 receptors modulates signalling. Br. J.
Pharmacol. 171, 5387–5406 (2014).
Carter, R. L. et al. Dynamic mass
redistribution analysis of endogenous b -adrenergic receptor signaling in
neonatal rat cardiac fibroblasts. Pharma. Res. Per. 2, 1–16
(2014).
Teutsch, C. et al. Detection of free
fatty acid receptor 1 expression : the critical role of negative and positive
controls. Diabetologia 57, 776–780 (2014).
Meister, J. et al. The G Protein-coupled
Receptor P2Y 14 Influences Insulin Release and Smooth Muscle Function in Mice. J.
Biol. Chem. 289, 23353–23366 (2014).
Andradas, C. et al. Targeting CB 2
-GPR55 Receptor Heteromers Modulates Cancer Cell Signaling. J. Biol. Chem. 289, 21960–21972 (2014).
Schmitz, J. et al. Dualsteric Muscarinic
Antagonists − Orthosteric Binding Pose Controls Allosteric Subtype Selectivity. J. Med. Chem. 57, 6739–6750 (2014).
Mackenzie, A. E. et al. The Antiallergic
Mast Cell Stabilizers Lodoxamide and Bufrolin as the First High and Equipotent
Agonists of Human and Rat GPR35. Mol. Pharmacol. 85, 91–104
(2014).
Chen, X. et al. Rational Design of
Partial Agonists for the Muscarinic M1 Acetylcholine Receptor. J. Med. Chem. 58, 560–576 (2014).
Ferrie, A. M., Zaytseva, N. & Fang,
Y. Divergent Label-free Cell Phenotypic Overexpressed b2-Adrenergic Receptors. Sci.
Rep. 4, 3828 (2014).
Orgovan, N. et al. Dependence of cancer
cell adhesion kinetics on integrin ligand surface density measured by a
high-throughput label-free resonant waveguide grating biosensor. Sci. Rep. 4, 4034 (2014).
Sun, H. et al. Label-free cell
phenotypic profiling decodes the composition and signaling of an endogenous
ATP-sensitive potassium channel. Sci. Rep. 4, 4934 (2014).
2013
Sundström, L., Greasley, P. J., Engberg,
S., Wallander, M. & Ryberg, E. Succinate receptor GPR91 , a G ai coupled
receptor that increases intracellular calcium concentrations through PLC b. FEBS
Lett. 587, 2399–2404 (2013).
Fang, Y. Troubleshooting and deconvoluting
label-free cell phenotypic assays in drug discovery. J. Pharmacol. Toxicol.
Methods 67, 69–81 (2013).
Ahmedat, A. S. et al. Pro-fibrotic
processes in human lung fibroblasts are driven by an autocrine / paracrine
endothelinergic system. Br. J. Pharmacol. 168, 471–487 (2013).
Morse, M., Sun, H., Tran, E., Levenson,
R. & Fang, Y. Label-free integrative pharmacology on-target of opioid
ligands at the opioid receptor family. BMC Pharmacol. Toxicol. 14,
1–18 (2013).
Online, V. A., Ferrie, A. M., Wang, C.
& Fang, Y. Integrative Biology identifies an intracellular signalling wave
mediated through the b2-adrenergic receptor. Integr. Biol. 5,
1253–1261 (2013).
Christiansen, E. et al. Discovery of a
Potent and Selective Free Fatty Acid Receptor 1 Agonist with Low Lipophilicity
and High Oral Bioavailability. J. Med. Chem. 56, 982–992 (2013).
Hennig, D. et al. Novel Insights Into
Appropriate Encapsulation Methods for Bioactive Compounds Into Polymers: A
Study With Peptides and HDAC Inhibitors. Macromol. Biosci. 1–12 (2013).
Deng, H., Sun, H. & Fang, Y.
Label-free cell phenotypic assessment of the biased agonism and efficacy of
agonists at the endogenous muscarinic M3 receptors. J. Pharmacol. Toxicol.
Methods 68, 1–24 (2014).
Zaytseva, N. et al. Resonant waveguide
grating biosensor-enabled label-free and fluorescence detection of cell
adhesion. Sens. Actuators B Chem. 1–17 (2013).
Zhao, H., French, J. B., Fang, Y. &
Benkovic, S. J. The purinosome, a multi-protein complex involved in the de novo
biosynthesis of purines in humans. Chem. Commun. (Camb). 49, 1–17
(2014).
Cho, Y. & Baldán, A. Quest for New
Biomarkers in Atherosclerosis. Mo. Med. 110, 325–330 (2013).
Hennen, S. et al. Decoding Signaling and
Function of the Orphan G Protein– Coupled Receptor GPR17 with a Small-Molecule
Agonist. Sci. Signal. 6, 1–33 (2014).
Deng, H. & Fang, Y. The Three
Catecholics Benserazide, Catechol and Pyrogallol are GPR35 Agonists. Pharmaceuticals 6, 500–509 (2013).
Deng, H., Wang, C. & Fang, Y.
Label-free cell phenotypic assessment of the molecular mechanism of action of
epidermal growth factor receptor inhibitors. RSC Adv. 3,
10370–10378 (2013).
Schrage, R. et al. Agonists with
supraphysiological efficacy at the muscarinic M2 ACh receptor. Br. J.
Pharmacol. 169, 357–370 (2013).