OsteoProbe® RUO是在体测量骨组织材料性质的**仪器，是实验室和临床研究中测量骨质量的有力工具。OsteoProbe® RUO是一种便携式单手操作微压痕仪，与测量骨密度的放射性方法（X射线、DXA和CT）具有不同的原理，它使用参考点压痕技术来检测材料对局部压力的抵抗性。
应用范围：
OsteoProbe® RUO可测量骨组织的材料性质，有助于加深对骨量的认识。骨由矿物质和有机物（骨胶）组成，现有的技术只有提供有关矿物质的信息，关于有机物的信息很少。由于缺少在体测量方法，临床研究中难以得到骨的材料性质，参考点压痕技术则解决了这一难题，使得研究人员可以测量和监测骨量的改变。
OsteoProbe® RUO measures and quantifies material properties of bone, providing a clearer understanding of Bone Quality. Bone is composed of mineral and organic (Bone Glue) building blocks. Current techniques provide detailed information about the mineral aspect but we suffer from limited information about the organic. Learn more about Bone Quality.
In the clinical setting, material properties of Bone Quality have been ignored due to the lack of a method for in vivo measurement. Reference Point Indentation (RPI) is a technique bringing change to the current situation in a clinical research setting. RPI enables researchers to have an in vivo method for directly measuring material aspects of bone quality. With RPI, researchers can measure and monitor longitudinal changes in the material quality of bone.
相关文献：
[1] F. Malgo, N.A. Hamdy, S.E. Papapoulos, N.M. Appelman-Dijkstra. Bone Material Strength as measured by microindentation in vivo is decreased in patients with fragility fractures independently of Bone Mineral Density. J. Clin. Endocrinol. Metab., 100 (2012), pp. 2039-2045
[2] J.N. Farr, M.T. Drake, S. Amin, L.J.M. Iii, L.K. Mccready. In Vivo assessment of bone quality in postmenopausal women with type 2 diabetes. J. Bone Miner. Res. 29 (2014), pp. 787-795
OsteoProbe® RUO Publications
· Are the High Hip Fracture Rates Among Norwegian Women Explained by Impaired Bone Material Properties
Journal of Bone and Mineral Research, Dr. Erik Eriksen et al, 2015
· Bone Material Strength as measured by microindentation in vivo is decreased in patients with fragility fractures independently of Bone Mineral Density
Journal of Clinical Endocrinology & Metabolism, Dr. Socrates Papapoulos et al, 2015
· Bone Tissue Properties Measurement by Reference Point Indentation in Glucocorticoid-Induced Osteoporosis
Journal of Bone and Mineral Research, Dr. Adolfo Diez Perez et al, 2015
· Study of indentation of a sample equine bone using finite element simulation and single cycle reference point indentation
Journal of the Mechanical Behavior of Biomedical Materials, Dr. Henry Yang et al, 2015
· In Vivo assessment of bone quality in postmenopausal women with type 2 diabetes
Journal of Bone and Mineral Research, Dr. Sundeep Khosla et al, 2013
· Applications of a New Handheld Reference Point Indentation Instrument Measuring Bone Material Strength
Journal of Medical Devices, Dr. Paul Hansma, 2013
· A new device for performing reference point indentation without a reference probe
Review of Scientific Instruments, Dr. Paul Hansma, 2012