The first and only research instrument for direct measurement of bone material properties in vivo. Empowering the world’s top laboratory and clinical researchers to measure the material aspects of bone quality for the first time ever.
OsteoProbe® RUO (research use only) is a portable handheld microindenter, measures the ability of bone material to resist indentation, unlike radiological methods (X-ray, DXA and CT) that measure bone mineral density and bone mineral structure.
OsteoProbe® RUO uses Reference Point Indentation (RPI) technology to investigate the bone material’s ability to resist a localized force (resist separation of mineralized collagen fibrils). This is quantified by the Bone Material Strength index (BMSi).
Every measurement taken is recorded in OsteoProbe’s software, providing the most accurate data.
No technical background is necessary to learn how to use OsteoProbe.
The first and only research instrument for direct measurement of bone material properties in vivo.
OsteoProbe® RUO measures and quantifies material properties of bone, providing a clearer understanding of Bone Quality. Bone is composed of mineral and organic (Bone Glue) building blocks. Current techniques provide detailed information about the mineral aspect but we suffer from limited information about the organic. Learn more about Bone Quality.
In the clinical setting, material properties of Bone Quality have been ignored due to the lack of a method for in vivo measurement. Reference Point Indentation (RPI) is a technique bringing change to the current situation in a clinical research setting. RPI enables researchers to have an in vivo method for directly measuring material aspects of bone quality. With RPI, researchers can measure and monitor longitudinal changes in the material quality of bone.
OsteoProbe® RUO uses Reference Point Indentation (RPI) technology to measure bone material’s ability to resist a localized force. Utilizing a probe specifically designed for percutaneous measurements, OsteoProbe penetrates soft tissue down to the bone surface (sans incision), establishing a local reference point. Once actuated, OsteoProbe measures the resistance to force and outputs a Bone Material Strength index (BMSi) score.
OsteoProbe® RUO was designed with the researcher in mind.
OsteoProbe® RUO allows quick and easy measurement of bone material property data without requiring extensive training. Simply attach a probe, connect a wire, and start taking measurements.
Learn more about using OsteoProbe® RUO.
OsteoProbe® RUO was invented to empower researchers with the tool they need to discover how genetics, disease, diet, exercise, and other triggers affect the quality of the bone tissue.
The bigger picture is that Reference Point Indentation was invented to enable scientists to discover better treatments, medical professionals can deliver better results, and people can live actively throughout their entire life. Learn more about the invention.
BioDent™ 骨等组织参考点压痕测试分析系统可以测量骨和其他组织的力学特性，具有离体测量和在体测量两种模式，可以直接在活体动物上在体测试分析骨等组织等力学特性；能获得以前无法获得的临床数据，如骨和其他组织的材料性质，对骨等组织尤为适用。 OsteoProbe® RUO为便携式在体/离体骨组织测量仪为BioDent™ 骨等组织参考点压痕测试分析系统手持版本
BioDent使用设计独特的微探针在微米水平上对组织施压。探针处于一个小套管内部(图2 A)，套管可在组织上或组织内部建立参考点，然后便可测量软、硬材料和生物材料的凹陷距离、相对刚度和能量耗散，从而**地检测材料力学性质(图2 B)。在恒力工作模式下，BioDent测量探针相对于参考点移动的距离，作为在此压力下材料发生的形变。在恒定距离工作模式（即将推出）下，BioDent测量使材料发生此种程度的形变时需要的力。
BioDent可临床测量材料性质作为健康或病变组织的指标。这些组织通常由不同的软硬组织在微米尺度上组合形成（图3），BioDent可在微米和毫米尺度上进行测量，以用于不同的生物材料。
OsteoProbe® RUO是在体测量骨组织材料性质的**仪器，是实验室和临床研究中测量骨质量的有力工具。OsteoProbe® RUO是一种便携式单手操作微压痕仪，与测量骨密度的放射性方法（X射线、DXA和CT）具有不同的原理，它使用参考点压痕技术来检测材料对局部压力的抵抗性。
OsteoProbe® RUO使用特别设计的探针来进行皮下测量，无须切开组织。探针刺空软组织达到骨表面建立一个参考点，当探针受力达到一个预先设定的阈值后会自动触发更大的力进行测量。软件会记录下来凹陷深度和力之间的函数关系，然后用聚甲基丙烯酸甲酯作为参照材料进行校准来获得BMSi（材料强度指数）。