CartiGen体外三维软骨组织机械力刺激培养分析系统能够为生物反应器内的生多种细胞和组织生长提供压应力培养。
培养室种类多样,单室可以容纳一个样本的直径30毫米x厚 5毫米的组织样品。
12孔培养室可以容纳大小不超过10毫米直径x 5毫米厚的12个样品,培养室种类多。
系统使用40N线型电机来监控/控制集成的负载细胞,提供各种波形,用户甚至可以自定义波形。
系统优势:
1.所有组件都可以高温高压**
2.换液过程中无需打开培养室,直接通过鲁尔接口配件完成换液。
3.轻量级设计,便于处理
4.表面容易清洗,耐腐蚀
5.紧凑的设计,符合标准6.5英尺孵化器
6.具有完善的售后服务体系,给你100%的满意,保质保修。
培养室型号
C10-12:反应器中可放进12个样品
C9-x :反应器中可放进9个样品
C1-x :反应器中可放进1个样品,直径可达25mm
参数
高度:266 mm
*大力值:44N
连续力值: 20N
重量:2.2KG
主要参数:
1.波形控制:正弦波形(自定义振幅和时间)
2. 无菌培养室体积:60毫升
3. Growthworks®控制系统软件:多波形控制,数据采集和多电机运行控制。
4. 4.200mmHg的压力峰值负荷
5. *大轴向行程长度为:±4.5mm(±3.75 mm,10 Hz)
6. 频率范围:0~20 Hz
7. 腔室个数:1~12个
8. 系统:直径30毫米x厚 5毫米
9. GrowthWorks可以配置为同时四个刺激器和同时监控多达8个传感器
10. *大轴向行程长度为:±4.5mm(±3.75 mm,10 Hz)
11. 集成光学传感器的位移测量系统
CartiGen: Mechanical Compression Bioreactor Systems
BISS TGT's Series of bioreactors provide mechanical stimulation to three dimensional tissue engineered constructs to create physiological conditions in-vitro. The CartiGen system imparts compressive or hydrostatic stress (CartiGen HP) to a cartilage construct. The stress/strain profiles can be defined by the user and can be a simple harmonic (sinusoidal) or a physiological waveform. Applications include the investigation of cell function and differentiation, pharmaceutical benchtop testing, and the seeding and growth of engineered tissues and medical devices. Researchers are currently utilizing these systems in a wide range of research areas including:
-
Stem cell stimulation
-
Meniscus regenerative medicine
-
Chondrocyte stimulation
Mechanical Compression Bioreactor Configurations:
BISS recognizes that research requirements can vary widely depending on the application and intended use. We have a series of standard mechanical compression bioreactor system configurations to choose from.
Single Sample: C10-1
The C10-1 system has been designed as a single sample bioreactor system that is able to support a wide range of cell and tissue growth experiments utilizing compression. The chamber can accommodate a single sample with a maximum size of 30 mm diameter x 5 mm thick. Optional features such as additional mechanical transducers customize the instrument for the specific research application.
Multi-Sample & Imaging: C10-12c
The C10-12c system has been designed as a multi-sample bioreactor system that is able to support a wide range of cell and tissue growth experiments. This chamber can accommodate up to 12 disc shaped samples with a maximum size of 10mm diameter x 5mm thick. The C10-12c's unique design includes optical grade windows on the bottom of the chamber, allowing researchers to view their samples with a confocol microscope without interrupting the culturing process. Optional features such as additional mechanical transducers customize the instrument for the specific research application.
Multi-Sample & Perfusion: C9-x
The C9-x system has been designed as a multi-sample bioreactor system that is able to support a wide range of cell and tissue growth experiments. The chamber can accommodate up to 9 disc shaped samples with a maximum size of 8mm diameter x 5mm thick. The C9-x's unique design integrates porous platens within the bottom of the chamber to permit perfusion through the sample constructs. This feature allows researchers to direct flow through the construct while applying oscillatory compressive stimulation. Optional features such as additional mechanical transducers and perfusion systems customize the instrument for the specific research application.
Bioreactor Stimulator
Each of the CartiGen systems applies load using a 40N linear motor and monitored/controlled using an integrated load cell. The motor also incorporates a displacement transducer for monitoring and controlling the applied displacement. The motor delivers user defined waveforms of physiological significance.
GrowthWorks® Software & Control:
A fifth generation design, the GrowthWorks Software and Control platform includes advanced capabilities, such as multiple waveform control, data acquisition and multi-motor operation. The intuitive software runs on a Windows® laptop computer and features a simple user interface. User defined stimulation profiles are controlled by the software and are readily monitored using graphical displays. Integrated data acquisition routines capture and record data at user prescribed intervals. The GrowthWorks Software is configurable for running four stimulators while simultaneously monitoring up to 16 transducers, allowing the researcher maximum flexibility.
The GrowthWorks Control Hardware features an embedded Intel CPU, integrated data acquisition and integrated motor drives. Communications between the laptop and control hardware is transmitted over a standard network cable. Primary advantages of the TGT Laptop/Controller approach are reduced physical size and easy upgradability. As future Windows versions or higher performance Laptops become available, either can be replaced without any software or controller changes. This ensures the GrowthWorks control system will be an integral part of your research for many years to come.
CARTILAGE
Key: S=Standard, A=Available, - = not available
CHAMBERS
|
C1
|
C10-12c
|
C9-x
|
Individual sample growth chamber
|
S
|
S
|
S
|
Multi-sample growth chamber
|
-
|
S
|
S
|
Perfusion and instrumentation ports per chamber
|
-
|
-
|
9
|
Max construct size: 30 mm diameter by 5 mm thick
|
S
|
-
|
-
|
Max construct size: 10 mm diameter by 5 mm thick
|
S
|
S
|
-
|
Max construct size: 6 mm diameter by 5 mm thick
|
S
|
S
|
S
|
Sample visualization via confocal microscopy
|
-
|
S
|
-
|
STIMULATION
|
C1
|
C10-12c
|
C9-x
|
Axial stimulator and reaction frame
|
S
|
S
|
S
|
Compressed air and manifold
|
-
|
-
|
-
|
CONTROLS
|
C1
|
C10-12c
|
C9-x
|
Controller software, computer, and monitor
|
S
|
S
|
S
|
Power supplies and cabling
|
S
|
S
|
S
|
Mean flow control
|
A
|
-
|
S
|
Dynamic flow control
|
A
|
-
|
S
|
TISSUE MONITORING
|
C1
|
C10-12c
|
C9-x
|
Non-contact flow sensors
|
A
|
A
|
A
|
Axial load cell
|
S
|
S
|
S
|
Pressure transducer
|
-
|
-
|
-
|
ACCESSORIES
|
C1
|
C10-12c
|
C9-x
|
Media reservoir
|
S
|
-
|
S
|
Incubator
|
A
|
A
|
A
|
BENEFITS
|
C1
|
C10-12c
|
C9-x
|
All-autoclavable components
|
S
|
S
|
S
|
Medium change without opening chamber via luer fittings
|
-
|
-
|
S
|
Increased sterility with fast and clean sample change and access
|
S
|
S
|
S
|
Lightweight design for easy handling
|
S
|
S
|
S
|
Easily cleaned surface finishes
|
S
|
S
|
S
|
Compact design for fit in standard incubators 6.5cubic ft
|
S
|
S
|
S
|
100% satisfaction guaranteed warranty
|
S
|
S
|
S
|
|