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Studies using FUS Instruments’ Systems
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Moyer, Linsey C., et al. “High-intensity focused ultrasound ablation enhancement
in vivo via phase-shift nanodroplets compared to microbubbles.” Journal of Therapeutic Ultrasound 3.1 (2015): 7.
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Ellens, N. P. K., et al. “The targeting accuracy
of a preclinical MRI-guided focused ultrasound system.” Medical physics 42.1 (2015): 430-439.
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Burgess, Alison, et al. “Alzheimer disease in a mouse model: MR imaging–guided
focused ultrasound targeted to the hippocampus opens the blood-brain barrier
and improves pathologic abnormalities and behavior.”Radiology 273.3 (2014):
736-745.
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Diaz, Roberto Jose, et al. “Focused ultrasound
delivery of Raman nanoparticles across the blood-brain barrier: Potential for
targeting experimental brain tumors.” Nanomedicine: Nanotechnology,
Biology and Medicine 10.5 (2014): 1075-1087.
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Nance, Elizabeth, et al. “Non-invasive delivery of
stealth, brain-penetrating nanoparticles across the blood− brain barrier
using MRI-guided focused ultrasound.” Journal of Controlled Release 189 (2014): 123-132.
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Oakden, Wendy, et al. “A non-surgical model of
cervical spinal cord injury induced with focused ultrasound and
microbubbles.” Journal of neuroscience
methods 235 (2014): 92-100.
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Phillips, Linsey C., et al. “Dual perfluorocarbon
nanodroplets enhance high intensity focused ultrasound heating and extend
therapeutic window in vivo.” The Journal of the Acoustical Society of America 134.5 (2013):
4049-4049.
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Alkins, Ryan D., et al. “Enhancing drug delivery
for boron neutron capture therapy of brain tumors
with focused ultrasound.” Neuro-oncology (2013):
not052.
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Alkins, Ryan, et al. “Focused ultrasound
delivers targeted immune cells to metastatic brain tumors.” Cancer research 73.6 (2013): 1892-1899.
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Huang, Yuexi, Natalia I. Vykhodtseva, and
Kullervo Hynynen. “Creating brain lesions
with low-intensity focused ultrasound with microbubbles: a rat study at half
a megahertz.” Ultrasound in medicine
& biology 39.8 (2013): 1420-1428.
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Jordão, Jessica F., et al. “Amyloid-β plaque
reduction, endogenous antibody delivery and glial activation by
brain-targeted, transcranial focused ultrasound.” Experimental neurology 248
(2013): 16-29.
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Scarcelli, Tiffany, et
al. “Stimulation of
hippocampal neurogenesis by transcranial focused ultrasound and microbubbles
in ***** mice.” Brain stimulation 7.2 (2013): 304-307.
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Etame, Arnold B., et al. “Enhanced delivery of
gold nanoparticles with therapeutic potential into the brain using MRI-guided
focused ultrasound.” Nanomedicine:
Nanotechnology, Biology and Medicine 8.7 (2012): 1133-1142.
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Thévenot, Emmanuel, et al. “Targeted delivery of
self-complementary adeno-associated virus serotype 9 to the brain, using
magnetic resonance imaging-guided focused ultrasound.” Human gene therapy 23.11 (2012): 1144-1155.
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Staruch, Robert, Rajiv
Chopra, and Kullervo Hynynen. “Hyperthermia in Bone
Generated with MR Imaging–controlled Focused Ultrasound: Control Strategies
and Drug Delivery.” Radiology 263.1 (2012):
117-127.
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Burgess, Alison, et al. “Targeted delivery of
neural stem cells to the brain using MRI-guided focused ultrasound to disrupt
the blood-brain barrier.” PLoS One 6.11 (2011):
e27877.
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Jordão, Jessica F., et al. “Antibodies targeted to
the brain with image-guided focused ultrasound reduces amyloid-β plaque load
in the TgCRND8 mouse model of Alzheimer’s disease.” PloS one 5.5 (2010): e10549.
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Blood-Brain Barrier Disruption Studies
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Leinenga, Gerhard, and Jürgen Götz. “Scanning ultrasound
removes amyloid-β and restores memory in an Alzheimer’s disease mouse model.” Science translational medicine 7.278 (2015): 278ra33-278ra33.
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Wang, S., et al. “Noninvasive,
neuron-specific gene therapy can be facilitated by focused ultrasound and
recombinant adeno-associated virus.” Gene Therapy 22.1 (2015):
104-110.
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McDannold, Nathan, et al. “Temporary disruption of
the blood–brain barrier by use of ultrasound and microbubbles: safety and
efficacy evaluation in rhesus macaques.” Cancer research 72.14 (2012): 3652-3663.
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Treat, Lisa H., et al. “Improved anti-tumor effect of liposomal doxorubicin
after targeted blood-brain barrier disruption by MRI-guided focused
ultrasound in rat glioma.” Ultrasound in medicine
& biology 38.10 (2012): 1716-1725.
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Kinoshita, Manabu, et al. “Noninvasive localized delivery of Herceptin to the mouse
brain by MRI-guided focused ultrasound-induced blood–brain barrier
disruption.” Proceedings of the
National Academy of Sciences 103.31 (2006): 11719-11723.
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Kinoshita, Manabu, et al. “Targeted delivery of antibodies through the blood–brain
barrier by MRI-guided focused ultrasound.” Biochemical and biophysical research communications 340.4
(2006): 1085-1090.
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Relevant Review Papers
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Burgess, Alison, and Kullervo Hynynen. “Drug delivery across the
blood-brain barrier using focused ultrasound.”Expert opinion on drug
delivery 11.5 (2014): 711-721.
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O’Reilly, Meaghan A., and
Kullervo Hynynen. “Ultrasound enhanced drug
delivery to the brain and central nervous system.” International Journal of Hyperthermia 28.4 (2012):
386-396.
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