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Vala Sciences品牌 IC200-KIC高内涵筛查系统
Vala Sciences IC200-KIC是一个功能齐全的高内涵筛查系统，也能够捕获高速时间序列图像。IC200使用基于图像的自动对焦和激光表面跟踪，确保每一个图像焦点聚焦。拥有很多物镜和孔板支持以及占用空间小的特点，IC200的功能全。灵活的模块化设计使得这个系统成为一个很好的定制解决方案的平台。
特点：
Publications:
I. Kinetic Image Cytometry:
1.
Wahlquist, C., Jeong, D., Rojas-Munoz, A., Kho, C., Lee,
A., Mitsuyama, S., van Mil, A., Park, W.J., Sluijter, J.P., Doevendans, P.A.,
Hajjar, R.J. & Mercola, M. Inhibition of miR-25 improves cardiac
contractility in the failing heart. Nature 508, 531-535 (2014).
2.
Cerignoli, F., Charlot, D., Whittaker, R., Ingermanson,
R., Gehalot, P., Savchenko, A., Gallacher, D.J., Towart, R., Price, J.H., McDonough,
P.M. & Mercola, M. High throughput measurement of Ca2+ dynamics for
drug risk assessment in human stem cell-derived cardiomyocytes by kinetic image
cytometry. J Pharmacol Toxicol Methods 66, 246-256 (2012).
3.
Islas, J.F., Liu, Y., Weng, K.C., Robertson, M.J., Zhang,
S., Prejusa, A., Harger, J., Tikhomirova, D., Chopra, M., Iyer, D., Mercola,
M., Oshima, R.G., Willerson, J.T., Potaman, V.N. & Schwartz, R.J.
Transcription factors ETS2 and MESP1 transdifferentiate human dermal
fibroblasts into cardiac progenitors. Proceedings of the National Academy of
Sciences of the United States of America 109, 13016-13021 (2012).
4.
Charlot, D., Campa, V., Azimi, B., Mercola, M.,
Ingermanson, R., McDonough, P.M. & Price, J.H. Automated calcium
measurements in live cardiomyocytes. in 5th IEEE International Symposium on
Biomedical Imaging: From Nano to Macro, Link. 316-319 (2008).
II. IC100 and IC200:
5.
Bharadwaj, U., Eckols, T.K., Kolosov, M., Kasembeli,
M.M., Adam, A., Torres, D., Zhang, X., Dobrolecki, L.E., Wei, W., Lewis, M.T.,
Dave, B., Chang, J.C., Landis, M.D., Creighton, C.J., Mancini, M.A. &
Tweardy, D.J. Drug-repositioning screening identified piperlongumine as a
direct STAT3 inhibitor with potent activity against breast cancer. Oncogene
0(2014).
6.
Bolt, M.J., Stossi, F., Callison, A.M., Mancini, M.G.,
Dandekar, R. & Mancini, M.A. Systems level-based RNAi screening by high
content analysis identifies UBR5 as a regulator of estrogen receptor-alpha
protein levels and activity. Oncogene (2014).
7.
Chung, T.D. Collaborative pre-competitive preclinical
drug discovery with academics and pharma/biotech partners at Sanford|Burnham:
infrastructure, capabilities & operational models. Combinatorial chemistry
& high throughput screening 17, 272-289 (2014).
8.
Stossi, F., Bolt, M.J., Ashcroft, F.J., Lamerdin, J.E.,
Melnick, J.S., Powell, R.T., Dandekar, R.D., Mancini, M.G., Walker, C.L.,
Westwick, J.K. & Mancini, M.A. Defining estrogenic mechanisms of bisphenol
A analogs through high throughput microscopy-based contextual assays. Chemistry
& biology 21, 743-753 (2014).
9.
Large, M.J., Wetendorf, M., Lanz, R.B., Hartig, S.M.,
Creighton, C.J., Mancini, M.A., Kovanci, E., Lee, K.F., Threadgill, D.W.,
Lydon, J.P., Jeong, J.W. & DeMayo, F.J. The epidermal growth factor
receptor critically regulates endometrial function during early pregnancy. PLoS
genetics 10, e1004451 (2014).
10. Bolt, M.J.,
Stossi, F., Newberg, J.Y., Orjalo, A., Johansson, H.E. & Mancini, M.A.
Coactivators enable glucocorticoid receptor recruitment to fine-tune estrogen
receptor transcriptional responses. Nucleic acids research 41, 4036-4048
(2013).
11. Castro, D.J.,
Maurer, J., Hebbard, L. & Oshima, R.G. ROCK1 inhibition promotes the self-renewal
of a novel mouse mammary cancer stem cell. Stem cells 31, 12-22 (2013).
12. Kostrominova,
T.Y., Reiner, D.S., Haas, R.H., Ingermanson, R. & McDonough, P.M. Automated
methods for the analysis of skeletal muscle fiber size and metabolic type.
International review of cell and molecular biology 306, 275-332 (2013).
13. McDonough, P.M.,
Maciejewski-Lenoir, D., Hartig, S.M., Hanna, R.A., Whittaker, R., Heisel, A.,
Nicoll, J.B., Buehrer, B.M., Christensen, K., Mancini, M.G., Mancini, M.A.,
Edwards, D.P. & Price, J.H. Differential phosphorylation of perilipin 1A at
the initiation of lipolysis revealed by novel monoclonal antibodies and high
content analysis. PloS one 8, e55511 (2013).
14. Prigozhina,
N.L., Heisel, A.J., Seldeen, J.R., Cosford, N.D. & Price, J.H. Amphiphilic
suramin dissolves Matrigel, causing an 'inhibition' artefact within in vitro
angiogenesis assays. International journal of experimental pathology 94,
412-417 (2013).
15. Dasgupta, I.,
Tanifum, E.A., Srivastava, M., Phatak, S.S., Cavasotto, C.N., Analoui, M. &
Annapragada, A. Non inflammatory boronate based glucose-responsive insulin
delivery systems. PloS one 7, e29585 (2012).
16. Ding, Z.,
German, P., Bai, S., Feng, Z., Gao, M., Si, W., Sobieski, M.M., Stephan, C.C.,
Mills, G.B. & Jonasch, E. Agents that stabilize mutated von Hippel-Lindau
(VHL) protein: results of a high-throughput screen to identify compounds that
modulate VHL proteostasis. Journal of biomolecular screening 17, 572-580
(2012).
17. Hartig, S.M.,
He, B., Newberg, J.Y., Ochsner, S.A., Loose, D.S., Lanz, R.B., McKenna, N.J.,
Buehrer, B.M., McGuire, S.E., Marcelli, M. & Mancini, M.A. Feed-forward
inhibition of androgen receptor activity by glucocorticoid action in human
adipocytes. Chemistry & biology 19, 1126-1141 (2012).
18. Slattery, S.D.,
Newberg, J.Y., Szafran, A.T., Hall, R.M., Brinkley, B.R. & Mancini, M.A. A
framework for image-based classification of mitotic cells in asynchronous
populations. Assay and drug development technologies 10, 161-178 (2012).
19. Uray, I.P.,
Rodenberg, J.M., Bissonnette, R.P., Brown, P.H. & Mancini, M.A.
Cancer-preventive rexinoid modulates neutral lipid contents of mammary
epithelial cells through a peroxisome proliferator-activated receptor
gamma-dependent mechanism. Molecular pharmacology 81, 228-238 (2012).
20. Zhang, X., Bolt,
M., Guertin, M.J., Chen, W., Zhang, S., Cherrington, B.D., Slade, D.J.,
Dreyton, C.J., Subramanian, V., Bicker, K.L., Thompson, P.R., Mancini, M.A.,
Lis, J.T. & Coonrod, S.A. Peptidylarginine deiminase 2-catalyzed histone H3
arginine 26 citrullination facilitates estrogen receptor alpha target gene
activation. Proceedings of the National Academy of Sciences of the United
States of America 109, 13331-13336 (2012).
21. Ashcroft, F.J.,
Newberg, J.Y., Jones, E.D., Mikic, I. & Mancini, M. High content imaging-based
assay to classify estrogen receptor-alpha ligands based on defined mechanistic
outcomes. Gene (2011).
22. Hartig, S.M.,
He, B., Long, W., Buehrer, B.M. & Mancini, M.A. Homeostatic levels of SRC-2
and SRC-3 promote early human adipogenesis. J Cell Biol 192, 55-67 (2011).
23. Prigozhina,
N.L., Heisel, A., Wei, K., Noberini, R., Hunter, E.A., Calzolari, D., Seldeen,
J.R., Pasquale, E.B., Ruiz-Lozano, P., Mercola, M. & Price, J.H.
Characterization of a novel angiogenic model based on stable, fluorescently
labelled endothelial cell lines amenable to scale-up for high content
screening. Biol Cell 103, 467-481 (2011).
24. Quintavalle, M.,
Elia, L., Price, J.H., Heynen-Genel, S. & Courtneidge, S.A. A cell-based
high-content screening assay reveals activators and inhibitors of cancer cell
invasion. Science signaling 4, ra49 (2011).
25. Yip, K.W.,
Cuddy, M., Pinilla, C., Giulanotti, M., Heynen-Genel, S., Matsuzawa, S. &
Reed, J.C. A high-content screening (HCS) assay for the identification of
chemical inducers of PML oncogenic domains (PODs). Journal of biomolecular
screening 16, 251-258 (2011).
26. Garcia-Becerra,
R., Berno, V., Ordaz-Rosado, D., Sharp, Z.D., Cooney, A.J., Mancini, M.A. &
Larrea, F. Ligand-induced large-scale chromatin dynamics as a biosensor for the
detection of estrogen receptor subtype selective ligands. Gene 458, 37-44
(2010).
27. Kiselyuk, A.,
Farber-Katz, S., Cohen, T., Lee, S.H., Geron, I., Azimi, B., Heynen-Genel, S.,
Singer, O., Price, J., Mercola, M., Itkin-Ansari, P. & Levine, F.
Phenothiazine neuroleptics signal to the human insulin promoter as revealed by
a novel high-throughput screen. Journal of biomolecular screening 15, 663-670
(2010).
28. McDonough, P.M.,
Ingermanson, R.S., Loy, P.A., Koon, E.D., Whittaker, R., Laris, C.A., Hilton,
J.M., Nicoll, J.B., Buehrer, B.M. & Price, J.H. Quantification of Hormone
Sensitive Lipase Phosphorylation and Colocalization with Lipid Droplets in
Murine 3T3L1 and Human Subcutaneous Adipocytes via Automated Digital Microscopy
and High-Content Analysis. Assay and drug development technologies (2010).
29. Narayanan, R.,
Yepuru, M., Szafran, A.T., Szwarc, M., Bohl, C.E., Young, N.L., Miller, D.D.,
Mancini, M.A. & Dalton, J.T. Discovery and mechanistic characterization of
a novel selective nuclear androgen receptor exporter for the treatment of
prostate cancer. Cancer Res 70, 842-851 (2010).
30. Whittaker, R.,
Loy, P.A., Sisman, E., Suyama, E., Aza-Blanc, P., Ingermanson, R.S., Price,
J.H. & McDonough, P.M. Identification of MicroRNAs that control lipid
droplet formation and growth in hepatocytes via high-content screening. Journal
of biomolecular screening 15, 798-805 (2010).
31. Zou, J., Ganji,
S., Pass, I., Ardecky, R., Peddibhotla, M., Loribelle, M., Heynen-Genel, S.,
Sauer, M., Pass, I., Vasile, S., Suyama, E., Malany, S., Mangravita-Novo, A.,
Vicchiarelli, M., McAnally, D., Cheltsov, A., Derek, S., Shi, S., Su, Y., Zeng,
F.Y., Pinkerton, A.B., Smith, L.H., Kim, S., Ngyuen, H., Zeng, F.Y., Diwan, J.,
Heisel, A.J., Coleman, R., McDonough, P.M. & Chung, T.D.Y. Potent
inhibitors of lipid droplet formation. in Probe Reports from the NIH Molecular
Libraries Program (Bethesda (MD), 2010).
32. Buck, T.E., Rao,
A., Coelho, L.P., Fuhrman, M.H., Jarvik, J.W., Berget, P.B. & Murphy, R.F.
Cell cycle dependence of protein subcellular location inferred from static,
asynchronous images. Conf Proc IEEE Eng Med Biol Soc 2009, 1016-1019 (2009).
33. Coelho, L.P.,
Shariff, A. & Murphy, R.F. Nuclear Segmentation in Microscope Cell Images:
A Hand-Segmented Dataset and Comparison of Algorithms. Proc IEEE Int Symp
Biomed Imaging 5193098, 518-521 (2009).
34. Giordano, C.,
Cui, Y., Barone, I., Ando, S., Mancini, M.A., Berno, V. & Fuqua, S.A.
Growth factor-induced resistance to tamoxifen is associated with a mutation of
estrogen receptor alpha and its phosphorylation at serine 305. Breast Cancer
Res Treat 119, 71-85 (2009).
35. Heynen-Genel, S.
& Price, J. Cytometric Features of Fluorescently Labeled Nuclei for Cell
Classification. in Handbook of Medical Image Processing and Analysis, Vol. 1
(ed. Bankman, I.) 453-463 (Academic Press, 2009).
36. McDonough, P.M.,
Agustin, R.M., Ingermanson, R.S., Loy, P.A., Buehrer, B.M., Nicoll, J.B.,
Prigozhina, N.L., Mikic, I. & Price, J.H. Quantification of Lipid Droplets
and Associated Proteins in Cellular Models of Obesity via
High-Content/High-Throughput Microscopy and Automated Image Analysis. Assay and
drug development technologies (2009).
37. Slattery, S.D.,
Mancini, M.A., Brinkley, B.R. & Hall, R.M. Aurora-C kinase supports mitotic
progression in the absence of Aurora-B. Cell Cycle 8, 2984-2994 (2009).
38. Szafran, A.T.,
Hartig, S., Sun, H., Uray, I.P., Szwarc, M., Shen, Y., Mediwala, S.N., Bell,
J., McPhaul, M.J., Mancini, M.A. & Marcelli, M. Androgen receptor mutations
associated with androgen insensitivity syndrome: a high content analysis
approach leading to personalized medicine. PloS one 4, e8179 (2009).
39. Willems, E.,
Bushway, P.J. & Mercola, M. Natural and synthetic regulators of embryonic
stem cell cardiogenesis. Pediatr Cardiol 30, 635-642 (2009).
40. Berno, V.,
Amazit, L., Hinojos, C., Zhong, J., Mancini, M. G., Sharp, Z. D., Mancini, M.
A. Activation of estrogen receptor-alpha by E2 or EGF induces temporally
distinct patterns of large-scale chromatin modification and mRNA transcription.
PloS one 3, e2286 (2008).
41. Bushway, P.J.,
Mercola, M. & Price, J.H. A comparative analysis of standard microtiter
plate reading versus imaging in cellular assays. Assay and drug development
technologies 6, 557-567 (2008).
42. Szafran, A.T.,
Szwarc, M., Marcelli, M. & Mancini, M.A. Androgen receptor functional
analyses by high throughput imaging: determination of ligand, cell cycle, and
mutation-specific effects. PloS one 3, e3605 (2008).
43. Amazit, L.,
Pasini, L., Szafran, A.T., Berno, V., Wu, R.C., Mielke, M., Jones, E.D.,
Mancini, M.G., Hinojos, C.A., O'Malley, B.W. & Mancini, M.A. Regulation of
SRC-3 intercompartmental dynamics by estrogen receptor and phosphorylation.
Molecular and cellular biology 27, 6913-6932 (2007).
44. Garcia Osuna,
E., Hua, J., Bateman, N.W., Zhao, T., Berget, P.B. & Murphy, R.F.
Large-scale automated analysis of location patterns in randomly tagged 3T3
cells. Ann Biomed Eng 35, 1081-1087 (2007).
45. Huang, Y., Qiu,
J., Dong, S., Redell, M.S., Poli, V., Mancini, M.A. & Tweardy, D.J. Stat3
isoforms, alpha and beta, demonstrate distinct intracellular dynamics with prolonged
nuclear retention of Stat3beta mapping to its unique C-terminal end. The
Journal of biological chemistry 282, 34958-34967 (2007).
46. Prigozhina,
N.L., Zhong, L., Hunter, E.A., Mikic, I., Callaway, S., Roop, D.R., Mancini,
M.A., Zacharias, D.A., Price, J.H. & McDonough, P.M. Plasma membrane assays
and three-compartment image cytometry for high content screening. Assay and
drug development technologies 5, 29-48 (2007).
47. Berno, V.,
Hinojos, C.A., Amazit, L., Szafran, A.T. & Mancini, M.A. High-resolution, high-throughput
microscopy analyses of nuclear receptor and coregulator function. Methods
Enzymol 414, 188-210 (2006).
48. Cho, C.Y., Koo,
S.H., Wang, Y., Callaway, S., Hedrick, S., Mak, P.A., Orth, A.P., Peters, E.C.,
Saez, E., Montminy, M., Schultz, P.G. & Chanda, S.K. Identification of the
tyrosine phosphatase PTP-MEG2 as an antagonist of hepatic insulin signaling.
Cell Metab 3, 367-378 (2006).
49. Marcelli, M.,
Stenoien, D.L., Szafran, A.T., Simeoni, S., Agoulnik, I.U., Weigel, N.L.,
Moran, T., Mikic, I., Price, J.H. & Mancini, M.A. Quantifying effects of
ligands on androgen receptor nuclear translocation, intranuclear dynamics, and
solubility. J Cell Biochem 98, 770-788 (2006).
50. Mikic, I.,
Planey, S., Zhang, J., Ceballos, C., Seron, T., von Massenbach, B., Watson, R.,
Callaway, S., McDonough, P.M., Price, J.H., Hunter, E. & Zacharias, D. A
live cell, image-based approach to understanding the enzymology and
pharmacology of 2-bromopalmitate and palmitoylation. Methods Enzymol 414,
150-187 (2006).
51. Mukherji, M.,
Bell, R., Supekova, L., Wang, Y., Orth, A.P., Batalov, S., Miraglia, L.,
Huesken, D., Lange, J., Martin, C., Sahasrabudhe, S., Reinhardt, M., Natt, F.,
Hall, J., Mickanin, C., Labow, M., Chanda, S.K., Cho, C.Y. & Schultz, P.G.
Genome-wide functional analysis of human cell-cycle regulators. Proceedings of
the National Academy of Sciences of the United States of America 103,
14819-14824 (2006).
52. Prigozhina, N.L.
& Waterman-Storer, C.M. Decreased polarity and increased random motility in
PtK1 epithelial cells correlate with inhibition of endosomal recycling. J Cell
Sci 119, 3571-3582 (2006).
53. Sharp, Z.D.,
Mancini, M.G., Hinojos, C.A., Dai, F., Berno, V., Szafran, A.T., Smith, K.P.,
Lele, T.P., Ingber, D.E. & Mancini, M.A. Estrogen-receptor-alpha exchange
and chromatin dynamics are ligand- and domain-dependent. J Cell Sci 119,
4101-4116 (2006).
54. Shen, F.,
Hodgson, L., Rabinovich, A., Pertz, O., Hahn, K. & Price, J.H. Functional
proteometrics for cell migration. Cytometry. Part A : the journal of the
International Society for Analytical Cytology 69, 563-572 (2006).
55. Shen, F. &
Price, J.H. Toward complete laser ablation of melanoma contaminant cells in a
co-culture outgrowth model via image cytometry. Cytometry. Part A : the journal
of the International Society for Analytical Cytology 69, 573-581 (2006).
56. Wilson, C.J.,
Si, Y., Thompsons, C.M., Smellie, A., Ashwell, M.A., Liu, J.F., Ye, P.,
Yohannes, D. & Ng, S.C. Identification of a small molecule that induces
mitotic arrest using a simplified high-content screening assay and data
analysis method. Journal of biomolecular screening 11, 21-28 (2006).
57. Harada, J.N.,
Bower, K.E., Orth, A.P., Callaway, S., Nelson, C.G., Laris, C., Hogenesch,
J.B., Vogt, P.K. & Chanda, S.K. Identification of novel mammalian growth
regulatory factors by genome-scale quantitative image analysis. Genome Res 15,
1136-1144 (2005).
58. Morelock, M.M.,
Hunter, E.A., Moran, T.J., Heynen, S., Laris, C., Thieleking, M., Akong, M.,
Mikic, I., Callaway, S., DeLeon, R.P., Goodacre, A., Zacharias, D. & Price,
J.H. Statistics of assay validation in high throughput cell imaging of nuclear
factor kappaB nuclear translocation. Assay and drug development technologies 3,
483-499 (2005).
59. Price, J.H.,
Goodacre, A., Hahn, K., Hodgson, L., Hunter, E.A., Krajewski, S., Murphy, R.F.,
Rabinovich, A., Reed, J.C. & Heynen, S. Advances in molecular labeling,
high throughput imaging and machine intelligence portend powerful functional
cellular biochemistry tools. J Cell Biochem Suppl 39, 194-210 (2002).
60. Bajaj, S.,
Welsh, J.B., Leif, R.C. & Price, J.H. Ultra-rare-event detection
performance of a custom scanning cytometer on a model preparation of fetal
nRBCs. Cytometry 39, 285-294 (2000).
III. CyteSeer Software Platform
61. Chung, C.H.,
Miller, A., Panopoulos, A., Hao, E., Margolis, R., Terskikh, A. & Levine,
F. Maternal embryonic leucine zipper kinase regulates pancreatic ductal, but
not beta-cell, regeneration. Physiological reports 2(2014).
62. Bhavane, R.,
Badea, C., Ghaghada, K.B., Clark, D., Vela, D., Moturu, A., Annapragada, A.,
Johnson, G.A., Willerson, J.T. & Annapragada, A. Dual-energy computed
tomography imaging of atherosclerotic plaques in a mouse model using a
liposomal-iodine nanoparticle contrast agent. Circulation. Cardiovascular
imaging 6, 285-294 (2013).
63. Mediwala, S.N.,
Sun, H., Szafran, A.T., Hartig, S.M., Sonpavde, G., Hayes, T.G., Thiagarajan,
P., Mancini, M.A. & Marcelli, M. The activity of the androgen receptor
variant AR-V7 is regulated by FOXO1 in a PTEN-PI3K-AKT-dependent way. The
Prostate 73, 267-277 (2013).
64. Zhang, Y.,
Davis, C., Sakellariou, G.K., Shi, Y., Kayani, A.C., Pulliam, D., Bhattacharya,
A., Richardson, A., Jackson, M.J., McArdle, A., Brooks, S.V. & Van Remmen,
H. CuZnSOD gene deletion targeted to skeletal muscle leads to loss of
contractile force but does not cause muscle atrophy in ***** mice. FASEB
journal : official publication of the Federation of American Societies for
Experimental Biology 27, 3536-3548 (2013).
65. Colas, A.R.,
McKeithan, W.L., Cunningham, T.J., Bushway, P.J., Garmire, L.X., Duester, G.,
Subramaniam, S. & Mercola, M. Whole-genome microRNA screening identifies
let-7 and mir-18 as regulators of germ layer formation during early
embryogenesis. Genes & development 26, 2567-2579 (2012).
66. Tanifum, E.A.,
Dasgupta, I., Srivastava, M., Bhavane, R.C., Sun, L., Berridge, J.,
Pourgarzham, H., Kamath, R., Espinosa, G., Cook, S.C., Eriksen, J.L. &
Annapragada, A. Intravenous delivery of targeted liposomes to amyloid-beta
pathology in APP/PSEN1 transgenic mice. PloS one 7, e48515 (2012).
67. Willems, E.,
Cabral-Teixeira, J., Schade, D., Cai, W., Reeves, P., Bushway, P.J., Lanier,
M., Walsh, C., Kirchhausen, T., Izpisua Belmonte, J.C., Cashman, J. &
Mercola, M. Small molecule-mediated TGF-beta type II receptor degradation
promotes cardiomyogenesis in embryonic stem cells. Cell stem cell 11, 242-252
(2012).
68. Larkin, L.M.,
Davis, C.S., Sims-Robinson, C., Kostrominova, T.Y., Van Remmen, H., Richardson,
A., Feldman, E.L. & Brooks, S.V. Skeletal muscle weakness due to deficiency
of CuZn-superoxide dismutase is associated with loss of functional innervation.
American journal of physiology. Regulatory, integrative and comparative
physiology 301, R1400-1407 (2011).
69. Willems, E.,
Spiering, S., Davidovics, H., Lanier, M., Xia, Z., Dawson, M., Cashman, J.
& Mercola, M. Small-molecule inhibitors of the Wnt pathway potently promote
cardiomyocytes from human embryonic stem cell-derived mesoderm. Circulation
research 109, 360-364 (2011).
70. Sun, S.,
Sprenger, C.C., Vessella, R.L., Haugk, K., Soriano, K., Mostaghel, E.A., Page,
S.T., Coleman, I.M., Nguyen, H.M., Sun, H., Nelson, P.S. & Plymate, S.R.
Castration resistance in human prostate cancer is conferred by a frequently
occurring androgen receptor splice variant. The Journal of clinical
investigation 120, 2715-2730 (2010).
71. McKeithan, W.L., Colas, A.R., Bushway, P.J., Ray, S.
& Mercola, M. Serum-Free Generation of Multipotent Mesoderm (Kdr+)
Progenitor Cells in Mouse Embryonic Stem Cells for Functional Genomics
Screening. in Current Protocols in Stem Cell Biology (John Wiley & Sons,
Inc., 2007).
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